The last word touches the reader's psyche more than any other, so make it count. 

Short, evocative nouns, adjectives and verbs are best. Here's a list for your inspiration: death, dead, kiss, lust, treachery, blood, fear, die, kill, deep, cold, heat, dark, boil, pull, grave, grip, grasp, hope, sear, scream, thrill, scar, bone, flesh, skull, wound, pray, pain, soul, child, flee, trap, teeth, curse, escape, safe, love. 

These words, on the other hand, have no particular effect: it, then, them, across, through, there, somehow, around,  under, of, off, for, that, be, others, his, her.

Often, restructuring the sentence is all it takes, or perhaps adding, deleting or replacing one word.

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I recommend backloading the last sentence of most paragraphs - but only if it suits the contents. If possible, backload the last sentence of every scene and story, because that's where the impact is greatest.